Cucurbitacin E

Cucurbitacin E is a biochemical compound from the family of Cucurbitacins. These are found in plants which are member of the family Cucurbitaceae, most of them coming from traditional Chinese medicinal plants, but also in other plants such as pumpkins and gourds.

Cucurbitacin E is a highly oxidated steroid consisting of a tetracyclic triterpene. Specific changes on this molecule under certain conditions can generate other types of Cucurbitacins such as Cucurbitacin I, J, K and L.

Nowadays it is being highly investigated because it has been discovered that this molecule has a wide range of biological properties that could help treating many diseases.

  • Anti-inflammatory.
  • Inhibition of the tumor growth through inhibiting tumor angiogenesis.
  • It has also been proved that Cucurbitacin E is an activator of T-lymphocytes and its effect increases when it is associated with PHA molecule.
  • Antioxidant properties.
  • Cytotoxic effect.
  • Cytostatic effect.
  • Hepatoprotecive effect
  • Insecticide effect [1]